Aileen Anderson, PhD
Professor, Physical Medicine & Rehabilitation;Director, Sue and Bill Gross Stem Cell Research Center
Neural stem cell transplantation for spinal cord injury. Interaction of donor and endogenous neural stem cells with the inflammatory microenvironment. Application of biomaterials in neuroregeneration and as scaffolds for neurorepair.
Shaista Malik, MD, PhD
Professor, Medicine; Associate Vice Chancellor, College of Health Sciences; Executive Director, Susan Samueli Integrative Health Institute
My research interests include assessment of both novel diagnostic and therapeutic modalities. In terms of assessing early heart disease, I work on a systems view of risk factors, including hypertension, metabolic syndrome as well as subclinical ... atherosclerosis, using genetic, proteomic and metabolomic biomarkers with imaging markers. In terms of therapeutic modalities, I am interested in examining clinical efficacy and identifying biological mechanisms of integrative therapies in those with subclinical and clinical cardiovascular risk factors for primary and secondary prevention. I having been working in the UCI Cardiovascular Acupuncture Research Program (CARP) and have specifically been engaged in the clinical translation of the use of electroacupuncture to treat hypertension and am currently investigating the molecular and neurobiological mechanisms associated with its effect.
Marcelo Wood, PhD
Professor & Chair, Neurobiology & Behavior
The research in my lab is focused on understanding the molecular mechanisms underlying learning and memory processes as well as drug-seeking behavior. I am particularly interested in examining the role of chromatin modifying enzymes in ... regulating transcription required for long-lasting types of memory and drug-seeking behavior. My lab uses a combined molecular, genetic, pharmacological and behavioral approach to examine the role of histone acetyltransferase (HAT) and histone deacetylase (HDAC) enzymes. Histone acetylation is one major epigenetic mechanism of gene regulation. We are also examining the role of a neuron-specific nucleosome remodeling complex (nBAF) in regulating gene expression required for memory processes that has been implicated in human intellectual disability disorders. Nucleosome remodeling represents another major epigenetic mechanism. The overall hypothesis driving our research is that epigenetic mechanisms modulate neuronal function in dynamic yet potentially very stable ways that underlie long-term changes in behavior related to memory processes and drug-seeking behavior. In addition, my lab also examines the role of these epigenetic gene regulation mechanisms in the context of the aging brain, ameliorating age-dependent cognitive decline, as well as in mouse models of neurodegenerative disease.
Advisory Committee for CNCM Viral Production Facility Services
Christine Gall, PhD
Professor & Chair, Anatomy & Neurobiology
TheI have focuary research is into mechanisms of synaptic plasticity underlying learning. This included work with animal models for autism and mental retardation (considered neurodevelopmental intellectual disability models), analysis of ... synaptic mechanisms of plasticity (receptors and signaling) and circuit arrangements underlying network activity with normal cognitive function, impairment, and plasticity. I have a particular interest in sex differences in cognitive processes and their impairment in disease conditions. The focus is on hippocampus and associated cortical fields