The Center for Neural Circuit Mapping (CNCM) is currently administered by the UCI School of Medicine (SOM) Office of Research. Leveraging their multiple NIH BRAIN Initiative Awards, other NIH grants and collaborations, SOM faculty Xiangmin Xu, Rozanne Sandri-Goldin, Todd Holmes and Bert Semler developed the Center plan which was recommended by the Dean’s Research Council and approved by the Dean on January 27, 2020.
This Center focuses on neural circuit studies and new neurotechnology development. The main aim of the Center is to advance the study of neural circuits to define mechanisms and pathways that underlie neurodevelopmental, neuropsychiatric and neurodegenerative disorders. Understanding the brain’s neural circuitry is critical for successful translational progress in better treating these diseases. Given the increasingly inter-disciplinary nature of neural circuit analysis, this Center will emphasize collaborative inclusion of Engineering, Pharmaceutical Sciences, Physical Sciences and Computer Science faculty on Campus.
One critical component of the Center is the creation of a viral production facility to disseminate to the worldwide neuroscience community new molecular tools developed by the Center investigators funded by BRAIN Initiative awards. This Center facility will also support UCI basic and clinical investigators using viral genetic tools, and locally serve the UCI research community by custom-making genetically modified AAV, lentivirus, rabies and herpes viruses, etc. on a recharge basis.
The CNCM membership is potentially available to all UCI faculty and faculty at partner institutions. More than 100 faculty members have joined the Center, including those from UCI, US national, and international institutions. We expect that the establishment of this Center will improve our research and competitive edge for large scale funding and help to raise our institutional profile and the success of our neuroscience faculty.
News
- New U24 Grant for SCDPAIN: Focusing on CNS Mechanisms in Sickle Cell PainNIHs, National Centre for Complementary and Integrative Health has awarded a five-year U24 grant of ~$5 million to create a Sickle Cell Disease Pain Analgesia and…Continue Reading New U24 Grant for SCDPAIN: Focusing on CNS Mechanisms in Sickle Cell Pain
- Meeting report for the 2024 UC Irvine Center for neural circuit mapping conference: Brain cell types, circuits, and disordersWe are excited to share our latest publication in Molecular Psychiatry! The University of California Irvine (UCI) Center for Neural Circuit Mapping (CNCM) held its 4th…Continue Reading Meeting report for the 2024 UC Irvine Center for neural circuit mapping conference: Brain cell types, circuits, and disorders
- CNCM and the NSF-Simons CMCF new proposed conceptual framework is published in Nature MethodsProfs. Qing Nie (CMCF), Xiangmin Xu (CNCM) and colleagues discussed the integration of small-scale datasets with each other or with larger reference atlases, particularly in the…Continue Reading CNCM and the NSF-Simons CMCF new proposed conceptual framework is published in Nature Methods
- CNCM Newsletter #2We’re thrilled to announce the release of our newest newsletter! This edition acknowledges our members’ achievements and highlights what to look forward to this year and…Continue Reading CNCM Newsletter #2
- UC Irvine-led team reveals how TREM2 genetic mutation affects late-onset Alzheimer’sIrvine, Calif., Aug. 6, 2024 — Researchers led by the University of California, Irvine have discovered how the TREM2 R47H genetic mutation causes certain brain areas…Continue Reading UC Irvine-led team reveals how TREM2 genetic mutation affects late-onset Alzheimer’s
- CNCM is awarded $1.4 million NIH grant for Alzheimer’s disease research trainingThe UC Irvine Center for Neural Circuit Mapping has been awarded a five-year, $1.4 million National Institutes of Health T32 grant to establish a training program…Continue Reading CNCM is awarded $1.4 million NIH grant for Alzheimer’s disease research training