Tallie Z. Baram, MD, PhD
Professor, Pediatrics, Anatomy & Neurobiology
- Reward circuitry and its modulation by early life experience
- Interaction of stress and reward circuits ...
- Molecularly defined pathways and their specific contribution to network function
- Optogenetics, chemogenetics
- Sex differences in the above
Kevin Beier, PhD
Assistant Professor, Physiology & Biophysics
We are interested in elucidating the molecular and circuit basis of behavioral adaptation. We aim to understand both how network modules are recruited at different time points in experience-dependent learning and how different nodes in these ... networks contribute to learning, as well as identifying the molecular and circuit factors that underlie susceptibility to behavioral maladaptations such as drug addiction and depression.
Emiliana Borrelli, PhD
Professor, Microbiology & Molecular Genetics
Research in the Borrelli’s laboratory focuses on the dopaminergic system and in particular on the dopamine D2 receptor (D2R) one of the major receptor of the system. The D2 receptor by two isoforms generated by alternatively splice of the ... same gene. We study the implication of these receptors in neurological and neuropsychiatric disorders using mouse models carrying either the constitutive knockout of D2R or D2R cell-specific knockouts. These animals allowed the study of D2R as a whole or of each specific isoform and in specific neuronal types. These mice have been critical to analyze the specific function of D2R in vivo in substance use disorders. Studies in my laboratory are also analyzing complex neuronal circuits that control striatal responses affecting motor behavior and reward to food and addictive substances. In addition, we are elucidating mechanisms that underlie dyskinesia in response to the long-term L-DOPA therapy of Parkinson’s disease or as well as dopamine-related psychiatric disorders such as schizophrenia and other psychotic disorders.
Javier Diaz Alonso, PhD
Assistant Professor, Anatomy and Neurobiology
Our research focuses on understanding how the glutamatergic and endocannabinoid systems are organized dynamically at CNS synapses to enable synaptic plasticity and a wide array of cognitive and behavioral functions. We strive to identify ... the pathophysiological mechanisms whereby the disruption of synaptic organization can lead to some CNS pathologies.
Timothy Downing, PhD
Assistant Professor, Biomedical Engineering
Our research aims to understand how chemical and biophysical signals from the cell microenvironment influence gene regulatory (epigenetic) programs within human cells. We hope to elucidate how these epigenetic changes ultimately ... contribute to changes in cell fate and behavior
Christie Fowler, PhD
Associate Professor, Neurobiology & Behavior
The Fowler lab is focused on defining the genetic, epigenetic and neurobiological mechanisms underlying drug addiction, with a focus on nicotine and cannabis. Our research employs multiple cutting edge approaches to reveal the function of ... brain circuits, molecular and extracellular mechanisms in processes underlying the addiction trajectory. Through these efforts, we hope to ascertain novel targets to provide a foundation for the development of more efficacious therapeutics to treat addiction.
Zhi-Ling Guo, MD, PhD
Project Scientist, Susan-Samueli Integrative Health Institute and Department of Medicine
I have focused my research on neural control of cardiovascular responses for many years with a strong track record. Currently, I have engaged in the study on neural mechanisms by which peripheral nerve stimulation (including ... cardiovascular responses, using anatomical, biochemical, physiological, electrophysiological, pharmacological, and molecular approaches. I am interested in the development of novel research proposals to investigate further mechanisms underlying the neural control of the cardiovascular system.
Todd Holmes, PhD
Professor and Vice Chair, Physiology and Biophysics
My laboratory has developed pioneering approaches for understanding neural circuits and whole animal behavior. We focus on unraveling the functional operations of neurons in vivo with the goal of understanding integrative neural function from ... molecules to behavior. Recently, we have discovered novel phototransduction mechanisms that occur directly in neurons that rapidly modulate electrical excitability. Other recent projects include modeling human neurodegenerative diseases using Drosophila as a model system.
Greg Horwitz, PhD
Professor, Physiology and Biophysics, University of Washington
Our primary research interests are the neural mechanisms of vision and visually guided behavior. We are particularly interested in the circuitry of the early visual pathways that mediate the perception of color and luminance.
Kei Igarashi, PhD
Assistant Professor, Anatomy & Neurobiology
The Kei lgarashi laboratory at UC lrvine investigates:
- How our neuronal circuits enable associative memory in healthy brain? ...
- How these brain circuits become impaired in Alzheimer's disease? Can we restore impaired circuits?
To solve these problems. we are targetinq the entorhinal-hippocampal circuits. a core brain circuit for memory usinq optogenetic-assisted in vivo multi-unit spike and LFP recordings and olfactory-cued memorg behavior tasks.
Masashi Kitazawa, PhD
Assistant Professor, Medicine
My research centers on understanding the molecular pathogenesis of Alzheimer's disease (AD) and the impact of neuroinflammation elicited endogenously by disruption of physiological immune responses by aging, genetics or ... intrinsic/extrinsic risk factors. Through understanding the key cellular mechanisms, one of my goals is to develop better animal models that recapitulate a broad spectrum of human AD conditions including altered neuronal circuit network and cognitive decline for better pre-clinical models.
Albert La Spada, MD, PhD
Professor, Pathology, Laboratory Medicine & Neurology
Dr. La Spada's research is focused upon neurodegenerative disease, and he is seeking the molecular events that underlie neurodegeneration and neuron cell death in spinal & bulbar muscular atrophy (SBMA), spinocerebellar ataxia type 7 ... (SCA7), Huntington’s Disease, ALS, and Parkinson’s disease. He and his team have uncovered evidence for transcription dysregulation, perturbed bioenergetics, and altered protein quality control as contributing factors to neuron dysfunction. By reproducing molecular pathology in mice and in neurons derived from human patient stem cells, Dr. La Spada has begun to develop therapies to treat these disorders intended to boost the function of pathways of CNS homeostasis that decline with aging
Min-Hua Luo, MD, PhD
Professor, Center of Molecular Virology (WIV); Visiting Professor, Anatomy and Neurobiology, UCI
Our Neurovirology group has focused on neurotropic viruses and their neuropathogenesis (CMV), and the development of neurotropic viruses as effective neural circuit mapping tracers (HSV-1 strain H129). We use human CMV-infected neural ... stem cells and congenital MCMV-infected mouse embryos to study how CMV infection causes fetal brain developmental abnormalities and identify treatment strategies. We have developed anterograde multi-synaptic tracers (H129-G4 and variants), and anterograde mono-synaptic tracers (H129-dTK and variants). These tracers have been applied by neuroscientists worldwide. We currently work to improve these tracers.
Gyorgy Lur, PhD
Assistant Professor, Neurobiology & Behavior
The primary goal of my research is to understand how neurons summate synaptic input from various modalities and how changes in the cells’ neurochemical environment regulate this interaction. I am particularly interested in how sensory ... feed-forward and cognitive feed-back pathways integrate to facilitate perceptual decision making and how the stress induced degradation of this interaction affects cognitive performance.
Zoran Nenadic, DSc
Professor and Chair, BME, School of Engineering
Neuroengineering (brain-computer interfaces, multisensor extracellular recording); Biomedical signal processing and pattern recognition (supervised and unsupervised signal detection and classification); Large-scale in silico biological neural network models; Biomedical devices and sensors.
Douglas Nitz, PhD
Professor and Chair, UCSD Department of Cognitive Science
My research program studies the systems neuroscience of spatial cognition using freely behaving animal recordings and behavioral tasks combined with use of molecular tools for identification and manipulataion of specific neural circuits
Andre Obenaus, PhD
- Neuroimaging (magnetic resonance imaging, MRI) of disease
- Circuit mapping using diffusion tensor imaging (DTI) in health and in pathophysiology ...
- Vascular consequences of brain pathology and restoration of vascular networks
- Healthy aging and Alzheimer’s Disease
Sean Ostlund, PhD
Associate Professor, Anesthesiology & Perioperative Care
We study the neural underpinnings of motivated behavior and decision making in rodents. Our broad long-term goal is to advance understanding of the neurobehavioral processes that mediate adaptive reward-seeking behavior under normal ... conditions and how these processes go awry to produce pathological forms of reward seeking, such as in drug addiction. We address these questions by combining sophisticated behavioral assays with a variety of neuroscience techniques to measure (microdialysis and fast-scan cyclic voltammetry) and manipulate (opto- and chemogenetics) neural circuit function.
Lara Rangel, PhD
Assistant Professor, Cognitive Science, UCSD
Our projects combine computational and statistical models with in vivo electrophysiology to 1) identify elements within neural networks that give rise to rhythmically identifiable processing states and 2) test the impact of rhythmic coordination ... upon successful network engagement in rodent models. In addition, we record neural signals across microscopic, mesoscopic, and macroscopic scales in order to characterize the cellular and systems level processes that give rise to the electroencephalogram (EEG) signal and develop tools for translating the EEG signal into underlying local network dynamics.
Bing Ren, PhD
Professor, Cellular and Molecular Medicine, UCSD
I am directing the Center for Epigenomics at UCSD, which is a collaborative research center focused on development and application of cutting-edge tools to analyze the cells' epigenome in both normal and pathological conditions. The Center ... has established three technology platforms: (1) the automated, high throughput epigenomics platforms, such as ATAC-seq, ChlP-seq, Cut&Run; (2) single cell epigenomics assays such as single nucleus ATAC-seq, single nucleus RNA-seq, etc; (3) the high throughput spatial genomics and functional genomics assays, including multiplexed FISH, high through reporter assays
Rozanne Sandri-Goldin, PhD
Chancellor’s Professor and Chair, Microbiology and Molecular Genetics
The studies in my lab are focused on a multifunctional regulatory protein of herpes simplex virus (HSV-1) termed ICP27. We are directing our studies toward a structural analysis of ICP27 and the creation of targeted mutations to determine the structure-function of ICP27 interactions.
Bradley Voytek, PhD
Associate Professor, Cognitive Science and Halıcıoğlu Data Science Institute, UCSD
Dr. Voytek's lab combines large-scale data science and machine learning to study how brain regions communicate with one another, and how that communication changes with development, aging, and disease.
Marcelo Wood, PhD
Professor & Chair, Neurobiology & Behavior
The research in my lab is focused on understanding the molecular mechanisms underlying learning and memory processes as well as drug-seeking behavior. I am particularly interested in examining the role of chromatin modifying enzymes in ... regulating transcription required for long-lasting types of memory and drug-seeking behavior. My lab uses a combined molecular, genetic, pharmacological and behavioral approach to examine the role of histone acetyltransferase (HAT) and histone deacetylase (HDAC) enzymes. Histone acetylation is one major epigenetic mechanism of gene regulation. We are also examining the role of a neuron-specific nucleosome remodeling complex (nBAF) in regulating gene expression required for memory processes that has been implicated in human intellectual disability disorders. Nucleosome remodeling represents another major epigenetic mechanism. The overall hypothesis driving our research is that epigenetic mechanisms modulate neuronal function in dynamic yet potentially very stable ways that underlie long-term changes in behavior related to memory processes and drug-seeking behavior. In addition, my lab also examines the role of these epigenetic gene regulation mechanisms in the context of the aging brain, ameliorating age-dependent cognitive decline, as well as in mouse models of neurodegenerative disease.
Zhaoxia Yu, PhD
Associate Professor, Statistics
My main research interests are developing statistical methods and models. I enjoy applying existing or my new statistical methods/tools to data collected by collaborators in various disciplines. Having been collaborating with Dr. Xiangmin Xu for two years, I am fascinated by the great potential of neuroscience.
Hu Zhao, DDS, PhD
Assistant Professor, College of Dentistry, Texas AM
Tissue clearing technique is becoming popular in recent years on studying brain and other neural tissue. By turning tissue transparent, intact organs can be directly visualized with a confocal microscope and 3-D images can be acquired without ... sectioning. Our lab has developed a new tissue clearing technique named PEG Associated Solvent System (PEGASOS). The PEGASOS method efficiently clears both hard and soft tissue to high transparency and protects endogenous fluorescence with no loss. PEGASOS is also the only current clearing method capable of clearing bones and teeth into fully transparency. Skull bone, teeth and femur can be turned into nearly invisible without losing GFP fluorescence. We were able to perform 3-D imaging for intact skull, mandible, femur or teeth with a confocal, 2-photon or light sheet microscope. Vasculature, nerves or fluorescence labelled cells deep inside of the organs could be directly visualized without sectioning. We aim to utilize tissue clearing based deep imaging to explore neural organization within brain, spinal cord and other body parts.