Yanxiao Zhang*, Maria Luisa Amaral*, Chenxu Zhu, Steven F. Grieco, Xiaomeng Hou, Lin Lin, Justin Buchanan, Liqi Tong, Sebastian Preissl, Xiangmin Xu, Bing Ren. Single-cell Epigenome Analysis Reveals Age-associated Decay of Heterochromatin Domains in Excitatory Neurons in the Mouse Brain. Nature Cell Research (In press).
Qiao Ye, Gocylen Gast, Xilin Su, Takashi Saito, Takaomi C. Saido, Todd C. Holmes, Xiangmin Xu (2022). Hippocampal neural circuit connectivity alterations in an Alzheimer’s disease mouse model revealed by monosynaptic rabies virus tracing. Neurobiol Dis. 2022 Jul 14;105820. doi: 10.1016/j.nbd.2022.105820. Online ahead of print.
Ding Quan Ng; Daniella Chan; Parisa Agrawal; Weian Zhao; Xiangmin Xu; Munjal Acharya, Alexandre Chan (2022). Evidence of Brain-Derived Neurotrophic Factor in Ameliorating Cancer-Related Cognitive Impairment: A Systematic Review of Human Studies. Crit Rev Oncol Hematol. 2022 Jun 17;176:103748. doi: 10.1016/j.critrevonc.2022.103748. Online ahead of print.
Kevin G. Johnston, S. F. G., Hai Zhang, Suoqin Jin, Xiangmin Xu*, Qing Nie*. racking Longitudinal Population Dynamics of Single Neuronal Calcium Signal Using SCOUT. Cell Reports Methods, doi:https://www.cell.com/cell-reports-methods/pdfExtended/S2667-2375(22)00065-0 (2022).
Xu Chen, Riccardo Calandrelli, John Girardini, Zhangming Yan, Zhiqun Tan, Xiangmin Xu, Sheng Zhong (2022) PHGDH expression increases with progression of Alzheimer’s disease pathology and symptoms. Cell Metabolism 2022 May 3;34(5):651-653. doi: 10.1016/j.cmet.2022.02.008.
Xiaoxiao Lin,, Lujia Chen, Amandine Jullienne, Arjang Salehi, Mary Hamer, Todd Holmes, Andre Obenaus*, Xiangmin Xu * (2022) Longitudinal dynamics of micro-vascular recovery after acquired cortical injury. Acta Neuropathologica Communications 10, 59 (2022). https://doi.org/10.1186/s40478-022-01361-4
Xiaoxiao Lin, Michelle Amalraj, Crisylle Blanton, Brenda Avila, Todd C. Holmes, Douglas A. Nitz, Xiangmin Xu (2021) Noncanonical projections to the hippocampal CA3 regulate spatial learning and memory by modulating the feedforward hippocampal trisynaptic pathway. PLOS Biology 2021 Dec 20;19(12):e3001127. doi: 10.1371/journal.pbio.3001127.
Xiaoxiao Lin, Lujia Chen; David Baglietto-Vargas; Qiao Ye; Frank M LaFerla; Douglas A. Nitz; Todd C. Holmes; Xiangmin Xu (2021) Spatial coding defects of hippocampal neural ensemble calcium activities in the triple-transgenic Alzheimer’s disease mouse model. Neurobiology of Disease https://doi.org/10.1016/j.nbd.2021.105562.
Zhaoxia Yu#, Michele Guindani, Steven F. Grieco, Lujia Chen, Todd C. Holmes, Xiangmin Xu# (2021) Beyond t-Test and ANOVA: applications of mixed-effects models for more rigorous statistical analysis in neuroscience research. Neuron https://doi.org/10.1016/j.neuron.2021.10.030
Jennifer Wong, Steven Grieco, Karoni Dutt, Luija Chen, Jacquelyn Thelin, George Andrew Inglis, Shangrila Parvin, Sandra Garraway, Xiangmin Xu, Alan Goldin, and Andrew Escayg (2021). Autistic-like behavior, spontaneous seizures, and increased neuronal excitability in a Scn8a mouse model. Neuropsychopharmacolog https://www.nature.com/articles/s41386-021-00985-9
Steven F. Grieco, Xin Qiao, Kevin Johnston, Lujia Che1, Renetta R. Nelson, Cary Lai, Todd C. Holmes, Xiangmin Xu (2021). Neuregulin signaling mediates the acute and sustained antidepressant effects of subanesthetic ketamine. Translational Psychiatry 2021 Feb 24;11(1):144. doi: 10.1038/s41398-021-01255-4. PMID: 33627623
XiaoTing Zheng, Kirstie J. Salinas, Dario X. Figueroa Velez, Taylor Nakayama, Xiaoxiao Lin, Xiangmin Xu, Sunil P. Gandhi. (2021) Host Interneurons Mediate Cortical Plasticity Reactivated by Embryonic Inhibitory Cell Transplantation. Nature Communications 2021 Feb 8;12(1):862. doi: 10.1038/s41467-021-21097-4. PMID: 33558487.
Yong-Jun Liu, Elizabeth Spangenberg, Bryan Tang, Todd C Holmes, Kim N Green, Xiangmin Xu. (2020) Microglia elimination increases neural circuit connectivity and activity in adult mouse cortex. J Neurosci. 2020 Dec 23; JN-RM-2140-20. doi: 10.1523/JNEUROSCI.2140-20.2020. Online ahead of print. PMID: 33380470
Xiangmin Xu, Todd C. Holmes, Min-Hua Luo, Kevin T. Beier, Gregory D. Horwitz, Fei Zhao, Wenbo Zeng, May Hui, Bert L. Semler, Rozanne M. Sandri-Goldin (2020) Viral vectors for neural circuit mapping and recent advances in trans-synaptic anterograde tracers. Neuron (PRIMER review article, accepted on 07/12/2020)
Steven F Grieco, Xin Qiao, Xiaoting Zheng, Yongjun Liu, Lujia Chen, Hai Zhang, Zhaoxia Yu, Jeffrey Gavornik, Cary Lai, Sunil Gandhi, Todd C Holmes, Xiangmin Xu (2020) Subanesthetic ketamine reactivates adult cortical plasticity to restore vision from amblyopia. Current Biology (in press, accepted on 07/01/2020)
Jun H, Bramian A, Soma S, Saito T, Saido TC, Igarashi KM (2020) Disrupted Place Cell Remapping and Impaired Grid Cells in a Knockin Model of Alzheimer’s Disease. Neuron 2020;S0896-6273(20)30477-3. doi:10.1016/j.neuron.2020.06.023
Michael G Frantz, Emily C Crouse, Guela Sokhadze, Taruna Ikrar, Céleste-Élise Stephany, Collins Nguyen, Xiangmin Xu*, Aaron W McGee* (2020) Layer 4 gates experience-dependent plasticity in visual cortex independent of a canonical microcircuit. Current Biology, August 3, 2020 https://doi.org/10.1016/j.cub.2020.05.067 * Co-corresponding Authors
Chenxu Zhu, Sebastian Preissl, Bing Ren (2020) Single-cell Multimodal Omics: The Power of Many. Nat Methods 2020 Jan;17(1):11-14. doi: 10.1038/s41592-019-0691-5.
Sophia C Levis, Brandon S Bentzley, Jenny Molet, Jessica L Bolton, Christina R Perrone, Tallie Z Baram, Stephen V Mahler (2019) On the early life origins of vulnerability to opioid addiction. Mol Psychiatry. 2019 Dec 10;10.1038/s41380-019-0628-5. doi: 10.1038/s41380-019-0628-5.
Mitchell R Farrell, Christina M Ruiz, Erik Castillo, Lauren Faget, Christine Khanbijian, Siyu Liu, Hannah Schoch, Gerardo Rojas, Michelle Y Huerta, Thomas S Hnasko, Stephen V Mahler (2019) Ventral pallidum is essential for cocaine relapse after voluntary abstinence in rats. Neuropsychopharmacology 2019 Dec;44(13):2174-2185. doi: 10.1038/s41386-019-0507-4. Epub 2019 Sep 2.
Yanjun Sun, Suoqin Jin, Xiaoxiao Lin, Lujia Chen, Xin Qiao, Li Jiang, Pengcheng Zhou, Kevin G. Johnston, Peyman Golshani, Qing Nie, Todd C. Holmes, Douglas A. Nitz*, Xiangmin Xu* (2019) CA1-projecting Subiculum Neurons Facilitate Object-Place Learning. Nat Neurosci. 2019 Nov;22(11):1857-1870. doi: 10.1038/s41593-019-0496-y. Epub 2019 Sep 23.
Chenxu Zhu, Miao Yu, Hui Huang, Ivan Juric, Armen Abnousi, Rong Hu, Jacinta Lucero, M Margarita Behrens, Ming Hu, Bing Ren (2019) An Ultra High-Throughput Method for Single-Cell Joint Analysis of Open Chromatin and Transcriptome. Nat Struct Mol Biol. 2019 Nov;26(11):1063-1070. doi: 10.1038/s41594-019-0323-x. Epub 2019 Nov 6.
Lisa S Baik, David D Au, Ceazar Nave, Alexander J Foden, Wendy K Enrriquez-Villalva, Todd C Holmes. (2019) Distinct mechanisms of Drosophila CRYPTOCHROME-mediated light-evoked membrane depolarization and in vivo clock resetting. Proc Natl Acad Sci U S A. 2019 Nov 12;116(46):23339-23344. doi: 10.1073/pnas.1905023116. Epub 2019 Oct 28.
Guoqiang Li, Yaping Liu, Yanxiao Zhang, Naoki Kubo, Miao Yu, Rongxin Fang, Manolis Kellis, Bing Ren (2019) Joint Profiling of DNA Methylation and Chromatin Architecture in Single Cells. Nat Methods 2019 Oct;16(10):991-993. doi: 10.1038/s41592-019-0502-z. Epub 2019 Aug 5.
Zhiling Guo *, Xiaoxiao Lin, Tracy Samaniego, Alexander Isreb, Stacey Cao, Shaista Malik, Todd C Holmes, Xiangmin Xu * (2019) Fos-CreER Based Genetic Mapping of Forebrain Regions Activated by Acupuncture. Journal of Comparative Neurology 2019 Oct 10. doi: 10.1002/cne.24789. [Epub ahead of print]
Stephen V Mahler, Zachary D Brodnik, Brittney M Cox, William C Buchta, Brandon S Bentzley, Julian Quintanilla, Zackary A Cope, Edwin C Lin, Matthew D Riedy, Michael D Scofield, Justin Messinger, Christina M Ruiz, Arthur C Riegel, Rodrigo A España, Gary Aston-Jones (2019) Chemogenetic Manipulations of Ventral Tegmental Area Dopamine Neurons Reveal Multifaceted Roles in Cocaine Abuse. J Neurosci. 2019 Jan 16;39(3):503-518. doi: 10.1523/JNEUROSCI.0537-18.2018. Epub 2018 Nov 16.